The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
LIG_SH2_SFK_2

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI004892 P09619 PDGFRB
PGFRB_HUMAN 		579 585 SSDGHEYIYVDPMQLPYDST TP 1NZV  
Homo sapiens (Human) 1106

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0405 competition binding in vitro Alonso,1995 support certain InteractionDetection
experimental MI:0096 pull down in vivo/in vitro Superti-Furga,1993 support certain InteractionDetection
experimental MI:0114 x-ray crystallography in vitro Lubman,2003 support certain InteractionDetection FeatureDetection
experimental MI:0065 isothermal titration calorimetry in vitro Lubman,2003 support certain InteractionDetection
experimental MI:0096 pull down in vivo/in vitro Mori,1993 support certain InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P06241) FYN_HUMAN IPR000980 (SH2 domain)
The Src homology 2 (SH2) domain is a protein domain of about 100 amino-acid residues first identified as a conserved sequence region between the oncoproteins Src and Fps 		146 246 [mitab][xml]
(P39688) FYN_MOUSE IPR000980 (SH2 domain)
The Src homology 2 (SH2) domain is a protein domain of about 100 amino-acid residues first identified as a conserved sequence region between the oncoproteins Src and Fps 		147 246 2.2/2.2 [mitab][xml]
(P12931) SRC_HUMAN IPR000980 (SH2 domain)
The Src homology 2 (SH2) domain is a protein domain of about 100 amino-acid residues first identified as a conserved sequence region between the oncoproteins Src and Fps 		149 248 [mitab][xml]
(P00524) SRC_RSVSA IPR000980 (SH2 domain)
The Src homology 2 (SH2) domain is a protein domain of about 100 amino-acid residues first identified as a conserved sequence region between the oncoproteins Src and Fps 		146 245 0.4/0.4 [mitab][xml]
(P07947) YES_HUMAN IPR000980 (SH2 domain)
The Src homology 2 (SH2) domain is a protein domain of about 100 amino-acid residues first identified as a conserved sequence region between the oncoproteins Src and Fps 		156 255 [mitab][xml]

o  Pathways

KEGG: The sequence P09619 is implicated in the following 19 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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