The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
LIG_SH2_SFK_2

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI004886 P03079 
MT_POVHA 		322 328 HQEEEEPQYEEIPIYLELLP TP 1AOT  
1AOU  
1LCJ  
1NZL  
1SHD  
1SPS  
Hamster polyomavirus 401

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0077 nuclear magnetic resonance in vitro Mulhern,1997 support certain InteractionDetection FeatureDetection
experimental MI:0114 x-ray crystallography in vitro Waksman,1993 support certain InteractionDetection FeatureDetection
experimental MI:0114 x-ray crystallography in vitro Eck,1993 support certain InteractionDetection FeatureDetection
experimental MI:0411 elisa in vitro Gilmer,1994 support certain InteractionDetection ParticipantIdentification
experimental MI:0074 mutation analysis in vivo/in vitro Gilmer,1994 support certain FeatureDetection
experimental MI:0114 x-ray crystallography in vitro Gilmer,1994 support certain InteractionDetection FeatureDetection
experimental MI:0405 competition binding in vitro Alonso,1995 support certain InteractionDetection
experimental MI:0065 isothermal titration calorimetry in vitro Bradshaw,1998 support certain InteractionDetection
experimental MI:0065 isothermal titration calorimetry in vitro Lubman,2003 support certain InteractionDetection
experimental MI:0114 x-ray crystallography in vitro Lubman,2003 support certain InteractionDetection FeatureDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Dunant,1997 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Dunant,1997 support certain FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P06241) FYN_HUMAN IPR000980 (SH2 domain)
The Src homology 2 (SH2) domain is a protein domain of about 100 amino-acid residues first identified as a conserved sequence region between the oncoproteins Src and Fps 		146 246 [mitab][xml]
(P39688) FYN_MOUSE IPR000980 (SH2 domain)
The Src homology 2 (SH2) domain is a protein domain of about 100 amino-acid residues first identified as a conserved sequence region between the oncoproteins Src and Fps 		147 246 3.3/3.3 [mitab][xml]
(P06239) LCK_HUMAN IPR000980 (SH2 domain)
The Src homology 2 (SH2) domain is a protein domain of about 100 amino-acid residues first identified as a conserved sequence region between the oncoproteins Src and Fps 		125 224 [mitab][xml]
(P12931) SRC_HUMAN IPR000980 (SH2 domain)
The Src homology 2 (SH2) domain is a protein domain of about 100 amino-acid residues first identified as a conserved sequence region between the oncoproteins Src and Fps 		149 248 [mitab][xml]
(P00524) SRC_RSVSA IPR000980 (SH2 domain)
The Src homology 2 (SH2) domain is a protein domain of about 100 amino-acid residues first identified as a conserved sequence region between the oncoproteins Src and Fps 		146 245 0.2/0.2 [mitab][xml]
Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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