The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI003692 P35568 IRS1
IRS1_HUMAN
896 899 PEPKSPGEYVNIEFGSDQSG TP --- Homo sapiens (Human) 1242

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0405 competition binding in vitro Skolnik,1993 support certain InteractionDetection
experimental MI:0968 biosensor Skolnik,1993 support certain InteractionDetection
experimental MI:0113 western blot in vitro Skolnik,1993 support certain ParticipantIdentification FeatureDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Skolnik,1993 support certain InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P62993) GRB2_HUMAN PF00017 (SH2)
SH2 domain
60 135 0.035/0.035 [mitab][xml]

o  Pathways

KEGG: The sequence P35568 is implicated in the following 20 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
feedback@elm.eu.org