The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI000386 P10747 CD28
CD28_HUMAN
191 194 RSRLLHSDYMNMTPRRPGPT TP 3WA4  
5GJH  
Homo sapiens (Human) 220

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0065 isothermal titration calorimetry in vitro Inaba,2017 support certain InteractionDetection
experimental MI:0114 x-ray crystallography in vitro Inaba,2017 support certain InteractionDetection FeatureDetection
experimental MI:0114 x-ray crystallography in vitro Higo,2013 support certain InteractionDetection FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(O89100) GRAP2_MOUSE PF00017 (SH2)
SH2 domain
58 132 [mitab][xml]
(P62993) GRB2_HUMAN PF00017 (SH2)
SH2 domain
60 135 [mitab][xml]

o  Pathways

KEGG: The sequence P10747 is implicated in the following 11 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: The eukaryotic linear motif resource - 2018 update. (PMID:29136216)

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