| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI004831 | P06400 RB1 RB_HUMAN |
600 | 609 | PLQNNHTAADMYLSPVRSPK | TP |
4ELL |
Homo sapiens (Human) | 928 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0405 | competition binding | in vitro | Burke,2012 | support | certain | InteractionDetection |
| experimental | MI:0065 | isothermal titration calorimetry | in vitro | Burke,2012 | support | certain | InteractionDetection |
| experimental | MI:0114 | x-ray crystallography | in vitro | Burke,2012 | support | certain | InteractionDetection FeatureDetection |
| experimental | MI:0573 | mutation disrupting interaction | in vivo/in vitro | Burke,2010 | support | certain | |
| experimental | MI:0077 | nuclear magnetic resonance | in vitro | Burke,2010 | support | certain | InteractionDetection FeatureDetection |
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | Burke,2010 | support | certain | FeatureDetection |
| experimental | MI:0065 | isothermal titration calorimetry | in vitro | Burke,2010 | support | certain | InteractionDetection |
| experimental | MI:0405 | competition binding | in vitro | Burke,2010 | support | certain | InteractionDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (P06400) RB_HUMAN | IPR002720
(Retinoblastoma-associated protein A-box)
Retinoblastoma-like and retinoblastoma-associated proteins may have a function in cell cycle regulation |
373 | 573 | [mitab][xml] | |
| (P06400) RB_HUMAN | IPR002719
(Retinoblastoma-associated protein, B-box)
This entry includes retinoblastoma-associated protein (RB, also known as pRb, RB, p1051), retinoblastoma-like protein 1 (RBL1, also known as p107) and retinoblastoma-like protein 2 (RBL2, also kno... |
646 | 765 | [mitab][xml] |
Pathways
- Bladder cancer
- Breast cancer
- Cell cycle
- Cellular senescence
- Chemical carcinogenesis receptor activation
- Chronic myeloid leukemia
- Cushing syndrome
- Endocrine resistance
- Epstein Barr virus infection
- Gastric cancer
- Glioma
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Human T cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human papillomavirus infection
- Kaposi sarcoma associated herpesvirus infection
- Melanoma
- Non small cell lung cancer
- Pancreatic cancer
- Pathways in cancer
- Prostate cancer
- Small cell lung cancer
- Viral carcinogenesis
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement