The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI004828 O00716 E2F3
E2F3_HUMAN
442 450 SLGEEEGISDLFDAYDLEKL TP --- Homo sapiens (Human) 465

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0065 isothermal titration calorimetry in vitro Liban,2016 support certain InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P06400) RB_HUMAN IPR002720 (Retinoblastoma-associated protein A-box)
Retinoblastoma-like and retinoblastoma-associated proteins may have a function in cell cycle regulation
373 573 1.2/1.2 [mitab][xml]
(P06400) RB_HUMAN IPR002719 (Retinoblastoma-associated protein, B-box)
This entry includes retinoblastoma-associated protein (RB, also known as pRb, RB, p1051), retinoblastoma-like protein 1 (RBL1, also known as p107) and retinoblastoma-like protein 2 (RBL2, also kno...
646 765 [mitab][xml]
(P28749) RBL1_HUMAN IPR002720 (Retinoblastoma-associated protein A-box)
Retinoblastoma-like and retinoblastoma-associated proteins may have a function in cell cycle regulation
385 578 7.0/7.0 [mitab][xml]
(P28749) RBL1_HUMAN IPR002719 (Retinoblastoma-associated protein, B-box)
This entry includes retinoblastoma-associated protein (RB, also known as pRb, RB, p1051), retinoblastoma-like protein 1 (RBL1, also known as p107) and retinoblastoma-like protein 2 (RBL2, also kno...
787 943 [mitab][xml]

o  Pathways

KEGG: The sequence O00716 is implicated in the following 23 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
feedback@elm.eu.org