The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI001546 Q07954 LRP1
LRP1_HUMAN
4501 4507 DPDKPTNFTNPVYATLYMGG TP --- Homo sapiens (Human) 4544

o  Instance evidence

Evidence classPSMI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0096 pull down in vivo/in vitro support certain InteractionDetection
experimental MI:0519 glutathione s tranferase tag in vitro Barnes,2003 support certain
experimental MI:0424 protein kinase assay in vivo Barnes,2003 support certain InteractionDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Barnes,2003 support certain InteractionDetection
experimental MI:0077 nuclear magnetic resonance in vitro Barnes,2003 support certain InteractionDetection FeatureDetection
experimental MI:0074 mutation analysis in vivo/in vitro Barnes,2003 support certain FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(O75553) DAB1_HUMAN PF00640 (PID)
Phosphotyrosine interaction domain (PTB/PID)
42 168 [mitab][xml]
(P29353) SHC1_HUMAN PF00640 (PID)
Phosphotyrosine interaction domain (PTB/PID)
162 318 [mitab][xml]

o  Switches



This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

o  Pathways

KEGG: The sequence Q07954 is implicated in the following 2 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: The eukaryotic linear motif resource - 2018 update. (PMID:29136216)

ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
feedback@elm.eu.org