The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI001549 P35546 Ret
RET_MOUSE
1057 1063 RSLPSTWIENKLYGMSDPNW TP 1UEF  
pdb:1UEF
Mus musculus (House mouse) 1115

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0107 surface plasmon resonance in vitro Shi,2004 support certain InteractionDetection FeatureDetection
experimental MI:0114 x-ray crystallography in vitro Shi,2004 support certain InteractionDetection FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P29353) SHC1_HUMAN PF00640 (PID)
Phosphotyrosine interaction domain (PTB/PID)
162 318 3.2/3.2 [mitab][xml]

o  Switches



This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

o  Pathways

KEGG: The sequence P35546 is implicated in the following 4 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: The eukaryotic linear motif resource - 2018 update. (PMID:29136216)

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