Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
---|---|---|---|---|---|---|---|---|
ELMI001552 | P21860 ERBB3 ERBB3_HUMAN |
1322 | 1328 | LEATDSAFDNPDYWHSRLFP | TP | --- | Homo sapiens (Human) | 1342 |
Instance evidence
Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
---|---|---|---|---|---|---|---|
experimental | MI:0019 | coimmunoprecipitation | in vivo/in vitro | Prigent,1994 | support | certain | InteractionDetection |
experimental | MI:0424 | protein kinase assay | in vivo/in vitro | Prigent,1994 | support | certain | InteractionDetection |
experimental | MI:0074 | mutation analysis | in vivo/in vitro | Prigent,1994 | support | certain | FeatureDetection |
Interactions
Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
---|---|---|---|---|---|
(P29353) SHC1_HUMAN | PF00640
(PID)
Phosphotyrosine interaction domain (PTB/PID) |
162 | 318 | [mitab][xml] |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000135:
Phosphorylation of Y1328 in the PTB-binding motif of Receptor tyrosine-protein kinase erbB-3 (ERBB3) induces binding to the SHC-transforming protein 1 (SHC1) protein.
Pathways
KEGG: The sequence P21860 is implicated in the following 7 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement