ELM - instance LIG_PTB_Phospho_1 in sequence P16144 at position 1590

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI001551	P16144 ITGB4 ITB4_HUMAN	1590	1596	SVVVEDLLPNHSYVFRVRAQ	TP	---	Homo sapiens (Human)	1822

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0096	pull down	in vivo/in vitro		support	certain	InteractionDetection
experimental	MI:0519	glutathione s tranferase tag	in vitro	Dans,2001	support	certain
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Dans,2001	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Dans,2001	support	certain	FeatureDetection

Interactions

Uniprot Id	Domain family	Domain Start	Domain End	Affinity Min/Max (µMol)	Notes
(P29353) SHC1_HUMAN	PF00640 (PID) Phosphotyrosine interaction domain (PTB/PID)	162	318	4.7/4.7	[mitab][xml]

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000141:

Phosphorylation of Y1596 in the PTB-binding motif of Integrin beta-4 (ITGB4) induces binding to the SHC-transforming protein 1 (SHC1) protein.

Pathways

KEGG: The sequence P16144 is implicated in the following 8 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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