ELM - instance LIG_PTB_Phospho_1 in sequence P05106 at position 779

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI001548	P05106 ITGB3 ITB3_HUMAN	779	785	NNPLYKEATSTFTNITYRGT	TP	2L1C	Homo sapiens (Human)	788

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0077	nuclear magnetic resonance	in vitro	Deshmukh,2010	support	certain	InteractionDetection FeatureDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Deshmukh,2010	support	certain	FeatureDetection

Interactions

Uniprot Id	Domain family	Domain Start	Domain End	Affinity Min/Max (µMol)	Notes
(P29353) SHC1_HUMAN	PF00640 (PID) Phosphotyrosine interaction domain (PTB/PID)	162	318		[mitab][xml]

Switches

This ELM instance is part of the following 4 switching mechanisms annotated at the switches.ELM resource:

SWTI000140:

Phosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to the SHC-transforming protein 1 (SHC1) protein.
SWTI000202:

Phosphorylation of T779 in the PTB-binding motif of Integrin beta-3 (ITGB3) inhibits its interaction with SHC-transforming protein 1 (SHC1).
SWTI000275:

While phosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to SHC-transforming protein 1 (SHC1), additional phosphorylation of Y773 further increases the strength of the interaction.
SWTI000293:

Phosphorylation of Integrin beta-3 (ITGB3) at Y785 switches the specificity of integrin from Kindlin-2 (Fermitin family homolog 2 (FERMT2)) to the adaptor protein SHC-transforming protein 1 (SHC1).

Pathways

KEGG: The sequence P05106 is implicated in the following 20 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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