Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
---|---|---|---|---|---|---|---|---|
ELMI001548 | P05106 ITGB3 ITB3_HUMAN |
779 | 785 | NNPLYKEATSTFTNITYRGT | TP |
2L1C |
Homo sapiens (Human) | 788 |
Instance evidence
Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
---|---|---|---|---|---|---|---|
experimental | MI:0077 | nuclear magnetic resonance | in vitro | Deshmukh,2010 | support | certain | InteractionDetection FeatureDetection |
experimental | MI:0074 | mutation analysis | in vivo/in vitro | Deshmukh,2010 | support | certain | FeatureDetection |
Interactions
Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
---|---|---|---|---|---|
(P29353) SHC1_HUMAN | PF00640
(PID)
Phosphotyrosine interaction domain (PTB/PID) |
162 | 318 | [mitab][xml] |
Switches
This ELM instance is part of the following 4 switching mechanisms annotated at the switches.ELM resource:
-
SWTI000140:
Phosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to the SHC-transforming protein 1 (SHC1) protein.
-
SWTI000202:
Phosphorylation of T779 in the PTB-binding motif of Integrin beta-3 (ITGB3) inhibits its interaction with SHC-transforming protein 1 (SHC1).
-
SWTI000275:
While phosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to SHC-transforming protein 1 (SHC1), additional phosphorylation of Y773 further increases the strength of the interaction.
-
SWTI000293:
Phosphorylation of Integrin beta-3 (ITGB3) at Y785 switches the specificity of integrin from Kindlin-2 (Fermitin family homolog 2 (FERMT2)) to the adaptor protein SHC-transforming protein 1 (SHC1).
Pathways
KEGG: The sequence P05106 is implicated in the following 20 Pathways: (color codes: This sequence=red, interacting sequence=orange)- Arrhythmogenic right ventricular cardiomyopathy
- Dilated cardiomyopathy
- ECM receptor interaction
- Fluid shear stress and atherosclerosis
- Focal adhesion
- Hematopoietic cell lineage
- Herpes simplex virus 1 infection
- Human cytomegalovirus infection
- Human papillomavirus infection
- Hypertrophic cardiomyopathy
- MicroRNAs in cancer
- Neutrophil extracellular trap formation
- Osteoclast differentiation
- PI3K Akt signaling pathway
- Phagosome
- Platelet activation
- Proteoglycans in cancer
- Rap1 signaling pathway
- Regulation of actin cytoskeleton
- Thyroid hormone signaling pathway
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement