The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI001539 P05106 ITGB3
ITB3_HUMAN
767 773 ARAKWDTANNPLYKEATSTF TP 2L1C  
pdb:2L1C
Homo sapiens (Human) 788

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0077 nuclear magnetic resonance in vitro Oxley,2008 support certain InteractionDetection FeatureDetection
experimental MI:0077 nuclear magnetic resonance in vitro Deshmukh,2010 support certain InteractionDetection FeatureDetection
experimental MI:0005 alanine scanning in vivo/in vitro/in silico Calderwood,2003 support certain FeatureDetection
experimental MI:0107 surface plasmon resonance in vitro Calderwood,2003 support certain InteractionDetection FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(Q99704) DOK1_HUMAN PF02174 (IRS)
PTB domain (IRS-1 type)
151 254 37.0/37.0 [mitab][xml]
(P29353) SHC1_HUMAN PF00640 (PID)
Phosphotyrosine interaction domain (PTB/PID)
162 318 [mitab][xml]
(Q9Y490) TLN1_HUMAN PF02174 (IRS)
PTB domain (IRS-1 type)
310 401 0.76/0.76 [mitab][xml]

o  Switches



This ELM instance is part of the following 2 switching mechanisms annotated at the switches.ELM resource:

o  Pathways

KEGG: The sequence P05106 is implicated in the following 15 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: The eukaryotic linear motif resource - 2018 update. (PMID:29136216)

ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
feedback@elm.eu.org