| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI001539 | P05106 ITGB3 ITB3_HUMAN |
767 | 773 | ARAKWDTANNPLYKEATSTF | TP |
2L1C 
|
Homo sapiens (Human) | 788 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0077 | nuclear magnetic resonance | in vitro | Oxley,2008 | support | certain | InteractionDetection FeatureDetection |
| experimental | MI:0077 | nuclear magnetic resonance | in vitro | Deshmukh,2010 | support | certain | InteractionDetection FeatureDetection |
| experimental | MI:0005 | alanine scanning | in vivo/in vitro/in silico | Calderwood,2003 | support | certain | FeatureDetection |
| experimental | MI:0107 | surface plasmon resonance | in vitro | Calderwood,2003 | support | certain | InteractionDetection FeatureDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (Q99704) DOK1_HUMAN | PF02174
(IRS)
PTB domain (IRS-1 type) |
151 | 254 | 37.0/37.0 | [mitab][xml] |
| (P29353) SHC1_HUMAN | PF00640
(PID)
Phosphotyrosine interaction domain (PTB/PID) |
162 | 318 | [mitab][xml] | |
| (Q9Y490) TLN1_HUMAN | PF02174
(IRS)
PTB domain (IRS-1 type) |
310 | 401 | 0.76/0.76 | [mitab][xml] |
Switches
This ELM instance is part of the following 2 switching mechanisms annotated at the switches.ELM resource:
-
SWTI000139:
Phosphorylation of Y773 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to the Docking protein 1 (DOK1) protein.
-
SWTI000277:
Phosphorylation of Y773 in Integrin beta-3 (ITGB3) switches the specificity of ITGB3 from Talin-1 (TLN1) to Docking protein 1 (DOK1), with a 2-fold decrease of the affinity for TLN1 and close to a 400-fold increase of the affinity for DOK1. This switch results in negative regulation of integrin activation.
Pathways
- Arrhythmogenic right ventricular cardiomyopathy
- Dilated cardiomyopathy
- ECM receptor interaction
- Fluid shear stress and atherosclerosis
- Focal adhesion
- Hematopoietic cell lineage
- Herpes simplex virus 1 infection
- Human cytomegalovirus infection
- Human papillomavirus infection
- Hypertrophic cardiomyopathy
- MicroRNAs in cancer
- Neutrophil extracellular trap formation
- Osteoclast differentiation
- PI3K Akt signaling pathway
- Phagosome
- Platelet activation
- Proteoglycans in cancer
- Rap1 signaling pathway
- Regulation of actin cytoskeleton
- Thyroid hormone signaling pathway
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement