| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI001541 | P04629 NTRK1 NTRK1_HUMAN |
490 | 496 | SGLQGHIIENPQYFSDACVH | TP |
1SHC 
|
Homo sapiens (Human) | 796 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0065 | isothermal titration calorimetry | in vitro | Zhou,1995 | support | certain | InteractionDetection |
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | Zhou,1995 | support | certain | FeatureDetection |
| experimental | MI:0077 | nuclear magnetic resonance | in vitro | Zhou,1995 | support | certain | InteractionDetection FeatureDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (P29353) SHC1_HUMAN | PF00640
(PID)
Phosphotyrosine interaction domain (PTB/PID) |
162 | 318 | [mitab][xml] |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000145:
Phosphorylation of Y496 in the PTB-binding motif of High affinity nerve growth factor receptor (NTRK1) induces binding to the SHC-transforming protein 1 (SHC1) protein.
Pathways
- Apoptosis
- Calcium signaling pathway
- Central carbon metabolism in cancer
- Inflammatory mediator regulation of TRP channels
- MAPK signaling pathway
- Neurotrophin signaling pathway
- PI3K Akt signaling pathway
- Pathways in cancer
- Ras signaling pathway
- Thyroid cancer
- Transcriptional misregulation in cancer
Diseases
- Sequence Variation VAR_068482 (Pos 492) has been implicated in Insensitivity To Pain, Congenital, With Anhidrosis; Cipa (OMIM:256800).
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement