The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI001541 P04629 NTRK1
NTRK1_HUMAN
490 496 SGLQGHIIENPQYFSDACVH TP 1SHC  
pdb:1SHC
Homo sapiens (Human) 796

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0065 isothermal titration calorimetry in vitro Zhou,1995 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Zhou,1995 support certain FeatureDetection
experimental MI:0077 nuclear magnetic resonance in vitro Zhou,1995 support certain InteractionDetection FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P29353) SHC1_HUMAN PF00640 (PID)
Phosphotyrosine interaction domain (PTB/PID)
162 318 [mitab][xml]

o  Switches



This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

o  Pathways

The sequence P04629 is implicated in the following 9 Pathways: (color codes: This sequence=red, interacting sequence=orange)

o  Diseases

  • Sequence Variation VAR_068482 (Pos 492) has been implicated in Insensitivity To Pain, Congenital, With Anhidrosis; Cipa (OMIM:256800).
Please cite: ELM 2016-data update and new functionality of the eukaryotic linear motif resource. (PMID:26615199)

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