| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI001571 | P05106 ITGB3 ITB3_HUMAN |
779 | 786 | NNPLYKEATSTFTNITYRGT | TP | --- | Homo sapiens (Human) | 788 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0018 | two hybrid | in vivo | Eigenthaler,1997 | support | certain | InteractionDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (Q9Y490) TLN1_HUMAN | PF02174
(IRS)
PTB domain (IRS-1 type) |
310 | 401 | [mitab][xml] |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000293:
Phosphorylation of Integrin beta-3 (ITGB3) at Y785 switches the specificity of integrin from Kindlin-2 (Fermitin family homolog 2 (FERMT2)) to the adaptor protein SHC-transforming protein 1 (SHC1).
Pathways
- Arrhythmogenic right ventricular cardiomyopathy
- Dilated cardiomyopathy
- ECM receptor interaction
- Fluid shear stress and atherosclerosis
- Focal adhesion
- Hematopoietic cell lineage
- Herpes simplex virus 1 infection
- Human cytomegalovirus infection
- Human papillomavirus infection
- Hypertrophic cardiomyopathy
- MicroRNAs in cancer
- Neutrophil extracellular trap formation
- Osteoclast differentiation
- PI3K Akt signaling pathway
- Phagosome
- Platelet activation
- Proteoglycans in cancer
- Rap1 signaling pathway
- Regulation of actin cytoskeleton
- Thyroid hormone signaling pathway
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement