The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI001559 P05106 ITGB3
ITB3_HUMAN
767 774 ARAKWDTANNPLYKEATSTF TP 1MK7  
pdb:1MK7 1MK9  
pdb:1MK9
Homo sapiens (Human) 788

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0114 x-ray crystallography in vitro Garcia-Alvarez,2003 support certain InteractionDetection FeatureDetection
experimental MI:0074 mutation analysis in vivo/in vitro Garcia-Alvarez,2003 support certain FeatureDetection
experimental MI:0077 nuclear magnetic resonance in vitro Oxley,2008 support certain InteractionDetection FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P54939) TLN1_CHICK PF02174 (IRS)
PTB domain (IRS-1 type)
310 401 [mitab][xml]
(Q9Y490) TLN1_HUMAN PF02174 (IRS)
PTB domain (IRS-1 type)
310 401 218.0/228.0 [mitab][xml]

o  Switches



This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

o  Pathways

KEGG: The sequence P05106 is implicated in the following 15 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: The eukaryotic linear motif resource - 2018 update. (PMID:29136216)

ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
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