The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI001564 P01130 LDLR
822 829 KNINSINFDNPVYQKTTEDE TP --- Homo sapiens (Human) 860

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0096 pull down in vivo/in vitro support certain InteractionDetection
experimental MI:0519 glutathione s tranferase tag in vitro Trommsdorff,1998 support certain
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Trommsdorff,1998 support certain InteractionDetection
experimental MI:0018 two hybrid in vivo Trommsdorff,1998 support certain InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(O75553) DAB1_HUMAN PF00640 (PID)
Phosphotyrosine interaction domain (PTB/PID)
42 168 [mitab][xml]

o  Pathways

KEGG: The sequence P01130 is implicated in the following 10 Pathways: (color codes: This sequence=red, interacting sequence=orange)

o  Diseases

  • Sequence Variation VAR_062383 (Pos 826) has been implicated in Hypercholesterolemia, Familial (OMIM:143890).
  • Sequence Variation VAR_005419 (Pos 828) has been implicated in Hypercholesterolemia, Familial (OMIM:143890).
Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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