ELM - instance LIG_PDZ_Class_2 in sequence Q02410 at position 832

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI001594	Q02410 APBA1 APBA1_HUMAN	832	837	KTMPAAMYRLLTAQEQPVYI	TP	1U38	Homo sapiens (Human)	837

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0018	two hybrid	in vivo	Long,2005	support	certain	InteractionDetection
experimental	MI:0077	nuclear magnetic resonance	in vitro	Long,2005	support	certain	InteractionDetection FeatureDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Long,2005	support	certain	FeatureDetection

Interactions

Uniprot Id	Domain family	Domain Start	Domain End	Affinity Min/Max (µMol)	Notes
(Q02410) APBA1_HUMAN	PF00595 (PDZ) PDZ domain (Also known as DHR or GLGF)				[mitab][xml]

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000327:

An intramolecular interaction of the C-terminal PDZ binding motif of Amyloid beta A4 precursor protein-binding family A member 1 (APBA1) (also known as X11alpha/Mint1) with the PDZ domain tandem of APBA1 results in an auto-inhibited conformation of APBA1, where binding of ligands containing a PDZ binding motif such as Presenilin-1 (PSEN1) is blocked. Binding of these ligands might be regulated by phosphorylation of Y836 in the APBA1 PDZ-binding motif, as its mutation to glutamate releases autoinhibition and enhances the interaction of the APBA1 PDZ tandem with presenilin.

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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