The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI002184 P49768 PSEN1
PSN1_HUMAN
462 467 ATDYLVQPFMDQLAFHQFYI TP --- Homo sapiens (Human) 467

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0018 two hybrid in vivo Xu,2000 support certain InteractionDetection
experimental MI:0403 colocalization in vitro Lau,2000 support certain
experimental MI:0429 necessary binding site Lau,2000 support certain
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Lau,2000 support certain InteractionDetection
experimental MI:0096 pull down in vivo/in vitro Lau,2000 support certain InteractionDetection

o  Switches



This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

o  Pathways

The sequence P49768 is implicated in the following 4 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM 2016-data update and new functionality of the eukaryotic linear motif resource. (PMID:26615199)

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