ELM - instance LIG_PDZ_Class_2 in sequence P19491 at position 878

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI001579	P19491 Gria2 GRIA2_RAT	878	883	QNFATYKEGYNVYGIESVKI	TP	2PKU	Rattus norvegicus (Norway rat)	883

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0077	nuclear magnetic resonance	in vitro	Pan,2007	support	certain	InteractionDetection FeatureDetection

Interactions

Uniprot Id	Domain family	Domain Start	Domain End	Affinity Min/Max (µMol)	Notes
(Q9EP80) PICK1_RAT	PF00595 (PDZ) PDZ domain (Also known as DHR or GLGF)	22	101		[mitab][xml]

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000593:

Alternative splicing removes the PDZ-binding motif of Glutamate receptor 2 (Gria2), abrogating binding to PRKCA-binding protein (Pick1). The presence of PDZ-binding motifs is also seen in the short isoforms of Gria3 (Isoform Flop) and Gria4 (Isoform 4C flop). PRKCA-binding protein (Pick1) recruits both Protein kinase C alpha type (Prkca) and Gria2 simultaneously, possibly allowing Pick1 to play a role in the selective targeting to and possible anchoring of GluRshort-containing AMPA receptors to intracellular membrane-associated Prkca.

Pathways

KEGG: The sequence P19491 is implicated in the following 15 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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