The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI001572 Q495M9 USH1G
USH1G_HUMAN
456 461 AVRRRRQAMERPPALEDTEL TP 3K1R  
pdb:3K1R
Homo sapiens (Human) 461

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0074 mutation analysis in vivo/in vitro Yan,2010 support certain FeatureDetection
experimental MI:0065 isothermal titration calorimetry in vitro Yan,2010 support certain InteractionDetection
experimental MI:0059 gst pull down in vivo/in vitro Yan,2010 support certain InteractionDetection
experimental MI:0114 x-ray crystallography in vitro Yan,2010 support certain InteractionDetection FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(Q9Y6N9) USH1C_HUMAN PF00595 (PDZ)
PDZ domain (Also known as DHR or GLGF)
1.0/1.0 [mitab][xml]

o  Diseases

  • Sequence Variation VAR_060468 (Pos 458) has been implicated in Usher Syndrome, Type Ig; Ush1g (OMIM:606943).
Please cite: ELM 2016-data update and new functionality of the eukaryotic linear motif resource. (PMID:26615199)

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