ELM - instance LIG_PDZ_Class_1 in sequence P51790-2 at position 861

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002608	P51790-2 CLCN3 CLCN3_HUMAN	861	866	TDEEREETEEEVYLLNSTTL	TP	---	Homo sapiens (Human)	866

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0007	anti tag coimmunoprecipitation	in vivo	Ogura,2002	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Ogura,2002	support	certain	FeatureDetection
experimental	MI:0096	pull down	in vivo/in vitro	Ogura,2002	support	certain	InteractionDetection

Interactions

Uniprot Id	Domain family	Domain Start	Domain End	Affinity Min/Max (µMol)	Notes
(O14745) NHRF1_HUMAN	PF00595 (PDZ) PDZ domain (Also known as DHR or GLGF)	154	231		[mitab][xml]

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000592:

Alternative splicing removes the PDZ-binding motif of Isoform ClC-3B of H(+)/Cl(-) exchange transporter 3 (CLCN3), abrogating binding to Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1). Isoform ClC-3B of H(+)/Cl(-) exchange transporter 3 (CLCN3) is expressed at the leading edge of membrane ruffles. The interaction of CLCN3 with SLC9A3R1 is important for localising outwardly rectifying chloride channels at the leading edge.

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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