The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI001574 P48050 KCNJ4
IRK4_HUMAN
440 445 ERMQASLPLDNISYRRESAI TP 3GJ9  
pdb:3GJ9
Homo sapiens (Human) 445

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0096 pull down in vivo/in vitro support certain InteractionDetection
experimental MI:0519 glutathione s tranferase tag in vitro Yan,2009 support certain
experimental MI:0065 isothermal titration calorimetry in vitro Yan,2009 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Yan,2009 support certain FeatureDetection
experimental MI:0114 x-ray crystallography in vitro Yan,2009 support certain InteractionDetection FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(O14907) TX1B3_HUMAN PF00595 (PDZ)
PDZ domain (Also known as DHR or GLGF)
17 110 [mitab][xml]

o  Switches



This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

o  Pathways

KEGG: The sequence P48050 is implicated in the following 2 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: The eukaryotic linear motif resource - 2018 update. (PMID:29136216)

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