ELM - instance LIG_PDZ_Class_1 in sequence P31424 at position 1198

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002119	P31424 Grm5 GRM5_RAT	1198	1203	SSPKYDTLIIRDYTQSSSSL	TP	2EGN	Rattus norvegicus (Norway rat)	1203

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0114	x-ray crystallography	in vitro	Sugi,2007	support	certain	InteractionDetection FeatureDetection
experimental	MI:0107	surface plasmon resonance	in vitro	Sugi,2007	support	certain	InteractionDetection FeatureDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Sugi,2007	support	certain	FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000334:

Binding of the PDZ-binding motif of General receptor for phosphoinositides 1-associated scaffold protein (Grasp) (Tamalin) to the Tamalin (Grasp) PDZ domain locks this protein in an auto-inhibited conformation. Binding of the PDZ-binding motif of Metabotropic glutamate receptor 5 (Grm5) to the Tamalin (Grasp) PDZ domain results in disruption of the weaker intramolecular Tamalin (Grasp) interactions. The PDZ-binding motif of Tamalin (Grasp) becomes available to interact with the PDZ domain of Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Magi2) (S-SCAM), which functions as a receptor for kinesin motor proteins. See also switch details.

Pathways

KEGG: The sequence P31424 is implicated in the following 10 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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