The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI002120 P13569 CFTR
CFTR_HUMAN
1475 1480 KPQIAALKEETEEEVQDTRL TP 1I92  
pdb:1I92
Homo sapiens (Human) 1480

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0096 pull down in vivo/in vitro support certain InteractionDetection
experimental MI:0519 glutathione s tranferase tag in vitro Short,1998 support certain
experimental MI:0114 x-ray crystallography in vitro Karthikeyan,2001 support certain InteractionDetection FeatureDetection
experimental MI:0047 far western blotting in vitro Short,1998 support certain InteractionDetection
experimental MI:0107 surface plasmon resonance in vitro Short,1998 support certain InteractionDetection FeatureDetection
experimental MI:0074 mutation analysis in vivo/in vitro Short,1998 support certain FeatureDetection
experimental MI:0113 western blot in vitro Short,1998 support certain ParticipantIdentification FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(O14745) NHRF1_HUMAN PF00595 (PDZ)
PDZ domain (Also known as DHR or GLGF)
[mitab][xml]

o  Switches



This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

o  Pathways

KEGG: The sequence P13569 is implicated in the following 7 Pathways: (color codes: This sequence=red, interacting sequence=orange) Reactome: The sequence P13569 is implicated in the following 7 Pathways:
Please cite: ELM 2016-data update and new functionality of the eukaryotic linear motif resource. (PMID:26615199)

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