| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI001599 | P09619 PDGFRB PGFRB_HUMAN |
1101 | 1106 | EQLPDSGCPAPRAEAEDSFL | TP |
1GQ5 
|
Homo sapiens (Human) | 1106 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0047 | far western blotting | in vitro | Karthikeyan,2002 | support | certain | InteractionDetection |
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | Karthikeyan,2002 | support | certain | FeatureDetection |
| experimental | MI:0114 | x-ray crystallography | in vitro | Karthikeyan,2002 | support | certain | InteractionDetection FeatureDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (O14745) NHRF1_HUMAN | PF00595
(PDZ)
PDZ domain (Also known as DHR or GLGF) |
[mitab][xml] |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000674:
Phosphorylation of S1104 in the PDZ-binding motif of Platelet-derived growth factor receptor beta (PDGFRB) by Beta-adrenergic receptor kinase 1 (ADRBK1) inhibits binding to Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1). Binding of Platelet-derived growth factor receptor beta (PDGFRB) to Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1) potentiates dimerisation and signalling of the receptor, while phosphorylation at S1104 desensitises the receptor.
Pathways
- Calcium signaling pathway
- Central carbon metabolism in cancer
- Choline metabolism in cancer
- EGFR tyrosine kinase inhibitor resistance
- Focal adhesion
- Gap junction
- Glioma
- Human papillomavirus infection
- JAK STAT signaling pathway
- MAPK signaling pathway
- Melanoma
- MicroRNAs in cancer
- PI3K Akt signaling pathway
- Pathways in cancer
- Phospholipase D signaling pathway
- Prostate cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement