ELM - instance LIG_PDZ_Class_1 in sequence O88602 at position 318

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002121	O88602 Cacng2 CCG2_MOUSE	318	323	QKDSKDSLHANTANRRTTPV	TP	---	Mus musculus (House mouse)	323

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0424	protein kinase assay	in vitro	Choi,2002	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Choi,2002	support	certain	FeatureDetection
experimental	MI:0113	western blot	in vitro	Choi,2002	support	certain	ParticipantIdentification FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000200:

Phosphorylation of T321 in the PDZ-binding motif of Voltage-dependent calcium channel gamma-2 subunit (Cacng2) by cAMP subfamily prevents binding to the PDZ domain of Disks large homolog 4 (Dlg4), an interaction involved in regulating synaptic targeting of AMPA-selective glutamate receptors.

Pathways

KEGG: The sequence O88602 is implicated in the following 7 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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