| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI002588 | Q16881-4 TXNRD1 TRXR1_HUMAN |
46 | 52 | KAYQEGRLQKLLKMNGPEDL | TP | --- | Homo sapiens (Human) | 550 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0096 | pull down | in vivo/in vitro | support | likely | InteractionDetection | |
| experimental | MI:0519 | glutathione s tranferase tag | in vitro | Damdimopoulos,2004 | support | likely | |
| experimental | MI:0663 | confocal microscopy | in vivo/in vitro | Damdimopoulos,2004 | support | likely | InteractionDetection |
| experimental | MI:0405 | competition binding | in vitro | Damdimopoulos,2004 | support | likely | InteractionDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (P03372) ESR1_HUMAN | PF00104
(Hormone_recep)
Ligand-binding domain of nuclear hormone receptor |
325 | 544 | [mitab][xml] | |
| (Q92731) ESR2_HUMAN | PF00104
(Hormone_recep)
Ligand-binding domain of nuclear hormone receptor |
278 | 494 | [mitab][xml] |
Switches
This ELM instance is part of the following 2 switching mechanisms annotated at the switches.ELM resource:
-
SWTI000481:
Alternative splicing removes the NRBOX motif of Q16881-4, abrogating binding to Estrogen receptor (ESR1). Unlike splice variants without the NRBOX motif, TrxR1b (also known as Isoform TXNRD1_v2) is identified within the nucleus. TrxR1b enhanced the transcriptional activity of the estrogen receptors ESR1 and ESR2, possibly by providing a reduced environment in the immediate vicinity of the ERs.
-
SWTI000482:
Alternative splicing removes the NRBOX motif of Q16881-4, abrogating binding to Estrogen receptor beta (ESR2). Unlike splice variants without the NRBOX motif, TrxR1b (also known as Isoform TXNRD1_v2) is identified within the nucleus. TrxR1b enhanced the transcriptional activity of the estrogen receptors ESR1 and ESR2, possibly by providing a reduced environment in the immediate vicinity of the ERs.
Please cite:
The Eukaryotic Linear Motif resource: 2022 release.
(PMID:34718738)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement