The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
LIG_NRBOX

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI002588 Q16881-4 TXNRD1
TRXR1_HUMAN 		46 52 KAYQEGRLQKLLKMNGPEDL TP --- Homo sapiens (Human) 550

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0096 pull down in vivo/in vitro support likely InteractionDetection
experimental MI:0519 glutathione s tranferase tag in vitro Damdimopoulos,2004 support likely
experimental MI:0663 confocal microscopy in vivo/in vitro Damdimopoulos,2004 support likely InteractionDetection
experimental MI:0405 competition binding in vitro Damdimopoulos,2004 support likely InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P03372) ESR1_HUMAN PF00104 (Hormone_recep)
Ligand-binding domain of nuclear hormone receptor 		325 544 [mitab][xml]
(Q92731) ESR2_HUMAN PF00104 (Hormone_recep)
Ligand-binding domain of nuclear hormone receptor 		278 494 [mitab][xml]

o  Switches



This ELM instance is part of the following 2 switching mechanisms annotated at the switches.ELM resource:
  • SWTI000481:
    ELM Switch SWTI000481
    Alternative splicing removes the NRBOX motif of Q16881-4, abrogating binding to Estrogen receptor (ESR1). Unlike splice variants without the NRBOX motif, TrxR1b (also known as Isoform TXNRD1_v2) is identified within the nucleus. TrxR1b enhanced the transcriptional activity of the estrogen receptors ESR1 and ESR2, possibly by providing a reduced environment in the immediate vicinity of the ERs.

  • SWTI000482:
    ELM Switch SWTI000482
    Alternative splicing removes the NRBOX motif of Q16881-4, abrogating binding to Estrogen receptor beta (ESR2). Unlike splice variants without the NRBOX motif, TrxR1b (also known as Isoform TXNRD1_v2) is identified within the nucleus. TrxR1b enhanced the transcriptional activity of the estrogen receptors ESR1 and ESR2, possibly by providing a reduced environment in the immediate vicinity of the ERs.
Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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