ELM - instance LIG_NRBOX in sequence Q15648 at position 644

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI000786	Q15648 MED1 MED1_HUMAN	644	650	NTKNHPMLMNLLKDNPAQDF	TP	1RJK	Homo sapiens (Human)	1581

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0114	x-ray crystallography	in vitro	Vanhooke,2004	support	certain	InteractionDetection FeatureDetection
not annotated		not specified		Coulthard,2003	not specified	not specified

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000264:

Binding of the 18258" target="_blank">3,3\',5-triiodo-L-thyronine ligand to the nuclear Thyroid hormone receptor alpha (THRA) makes the binding site for the NRBOX motif of Mediator of RNA polymerase II transcription subunit 1 (MED1) accessible.

Pathways

KEGG: The sequence Q15648 is implicated in the following 2 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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