ELM - instance LIG_NRBOX in sequence Q15596 at position 689

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI000783	Q15596 NCOA2 NCOA2_HUMAN	689	695	LKEKHKILHRLLQDSSSPVD	TP	1GWQ	Homo sapiens (Human)	1464

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0114	x-ray crystallography	in vitro	Warnmark,2002	support	certain	InteractionDetection FeatureDetection
experimental	MI:0004	affinity chromatography technology	in vivo/in vitro	Voegel,1998	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Voegel,1998	support	certain	FeatureDetection
not annotated		not specified			not specified	not specified

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000261:

Binding of the 24261" target="_blank">glucocorticoid ligand to the nuclear Glucocorticoid receptor (NR3C1) makes the binding site for the NRBOX motif of Nuclear receptor coactivator 2 (NCOA2) accessible.

Pathways

KEGG: The sequence Q15596 is implicated in the following 2 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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