The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI004668 Q6NZY4 ZCCHC8
ZCHC8_HUMAN
178 184 VLYFTNFCLDKLGQPLLNEN TP --- Homo sapiens (Human) 707

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0074 mutation analysis in vivo/in vitro Lingaraju,2019 support certain FeatureDetection
experimental MI:0405 competition binding in vitro Lingaraju,2019 support certain InteractionDetection
experimental MI:1247 microscale thermophoresis in vitro Lingaraju,2019 support certain InteractionDetection
experimental MI:0096 pull down in vivo/in vitro Lingaraju,2019 support certain InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P42285) MTREX_HUMAN IPR025696 (rRNA-processing arch domain)
The essential RNA helicase Mtr4 is an exosome-activating cofactor
582 841 0.192/0.462 [mitab][xml]
Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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