The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI004747 P39875 EXO1
576 584 SISGCTKVLQKFRYSSSFSG TP --- Saccharomyces cerevisiae S288c 702

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0018 two hybrid in vivo Goellner,2018 support certain InteractionDetection
experimental MI:1088 phenotype-based detection assay Goellner,2018 support certain InteractionDetection
experimental MI:0405 competition binding in vitro Goellner,2018 support certain InteractionDetection
experimental MI:0005 alanine scanning in vivo/in vitro/in silico Goellner,2018 support certain FeatureDetection
experimental MI:0573 mutation disrupting interaction in vivo/in vitro Goellner,2018 support certain

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P25847) MSH2_YEAST IPR007696 (DNA mismatch repair protein MutS, core)
Mismatch repair contributes to the overall fidelity of DNA replication and is essential for combating the adverse effects of damage to the genome
330 664 [mitab][xml]

o  Pathways

KEGG: The sequence P39875 is implicated in the following 1 Pathway: (color codes: This sequence=red, interacting sequence=orange)
Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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