The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI003322 Q9BQB4 SOST
SOST_HUMAN
114 126 PARLLPNAIGRGKWWRPSGP TP 3SOV  
Homo sapiens (Human) 213

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0065 isothermal titration calorimetry in vitro Holdsworth,2012 support certain InteractionDetection
experimental MI:0055 fluorescent resonance energy transfer Holdsworth,2012 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Holdsworth,2012 support certain FeatureDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Holdsworth,2012 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Bourhis,2011 support certain FeatureDetection
experimental MI:0114 x-ray crystallography in vitro Bourhis,2011 support certain InteractionDetection FeatureDetection
experimental MI:0411 elisa in vitro Bourhis,2011 support certain InteractionDetection ParticipantIdentification

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(O75197) LRP5_HUMAN PF00058 (Ldl_recept_b)
Low-density lipoprotein receptor repeat class B
9.0/9.0 [mitab][xml]
(O75581) LRP6_HUMAN PF00058 (Ldl_recept_b)
Low-density lipoprotein receptor repeat class B
9.0/9.0 [mitab][xml]
Please cite: ELM 2016-data update and new functionality of the eukaryotic linear motif resource. (PMID:26615199)

ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
feedback@elm.eu.org