ELM - instance LIG_LIR_Gen_1 in sequence Q96CV9 at position 175

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI004496	Q96CV9 OPTN OPTN_HUMAN	175	184	SSGSSEDSFVEIRMAEGEAE	TP	2LUE	Homo sapiens (Human)	577

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0096	pull down	in vivo/in vitro	Rogov,2013	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Rogov,2013	support	certain	FeatureDetection
experimental	MI:0065	isothermal titration calorimetry	in vitro	Rogov,2013	support	certain	InteractionDetection
experimental	MI:0519	glutathione s tranferase tag	in vitro	Rogov,2013	support	certain
experimental	MI:0077	nuclear magnetic resonance	in vitro	Rogov,2013	support	certain	InteractionDetection FeatureDetection
experimental	MI:0114	x-ray crystallography	in vitro	Rogov,2013	support	certain	InteractionDetection FeatureDetection
experimental	MI:0096	pull down	in vivo/in vitro		support	certain	InteractionDetection
experimental	MI:0416	fluorescence microscopy		Wild,2011	support	certain	InteractionDetection
experimental	MI:0663	confocal microscopy	in vivo/in vitro	Wild,2011	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Wild,2011	support	certain	FeatureDetection
experimental	MI:0519	glutathione s tranferase tag	in vitro	Wild,2011	support	certain
experimental	MI:0018	two hybrid	in vivo	Wild,2011	support	certain	InteractionDetection

Interactions

Uniprot Id	Domain family	Domain Start	Domain End	Affinity Min/Max (µMol)	Notes
(O95166) GBRAP_HUMAN	PF02991 (Atg8) Autophagy protein Atg8 ubiquitin like	13	116		[mitab][xml]
(Q9H0R8) GBRL1_HUMAN	PF02991 (Atg8) Autophagy protein Atg8 ubiquitin like	13	116	65.0/65.0	[mitab][xml]
(P60520) GBRL2_HUMAN	PF02991 (Atg8) Autophagy protein Atg8 ubiquitin like	13	116		[mitab][xml]
(Q9H492) MLP3A_HUMAN	PF02991 (Atg8) Autophagy protein Atg8 ubiquitin like	15	120	65.0/65.0	[mitab][xml]
(Q9GZQ8) MLP3B_HUMAN	PF02991 (Atg8) Autophagy protein Atg8 ubiquitin like	15	120	65.0/65.0	[mitab][xml]

Pathways

KEGG: The sequence Q96CV9 is implicated in the following 3 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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