The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI004467 Q14457 BECN1
BECN1_HUMAN
96 103 STESANSFTLIGEASDGGTM TP 6HOJ  
Homo sapiens (Human) 450

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0114 x-ray crystallography in vitro Birgisdottir,2019 support certain InteractionDetection FeatureDetection
experimental MI:0074 mutation analysis in vivo/in vitro Birgisdottir,2019 support certain FeatureDetection
experimental MI:0081 peptide array Birgisdottir,2019 support certain InteractionDetection
experimental MI:0096 pull down in vivo/in vitro Birgisdottir,2019 support certain InteractionDetection
experimental MI:0969 biolayer interferometry Birgisdottir,2019 support certain InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(O95166) GBRAP_HUMAN PF02991 (Atg8)
Autophagy protein Atg8 ubiquitin like
13 116 9.7/11.3 [mitab][xml]
(Q9H0R8) GBRL1_HUMAN PF02991 (Atg8)
Autophagy protein Atg8 ubiquitin like
13 116 7.9/8.0 [mitab][xml]
(Q9H492) MLP3A_HUMAN PF02991 (Atg8)
Autophagy protein Atg8 ubiquitin like
15 120 38.5/47.5 [mitab][xml]
(Q9GZQ8) MLP3B_HUMAN PF02991 (Atg8)
Autophagy protein Atg8 ubiquitin like
15 120 244.5/285.5 [mitab][xml]
(Q9BXW4) MLP3C_HUMAN PF02991 (Atg8)
Autophagy protein Atg8 ubiquitin like
21 126 82.9/101.1 [mitab][xml]

o  Pathways

KEGG: The sequence Q14457 is implicated in the following 12 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM — the eukaryotic linear motif resource in 2020. (PMID:31680160)

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