ELM - instance LIG_LIR_Gen_1 in sequence O75385 at position 356

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI004481	O75385 ULK1 ULK1_HUMAN	356	365	SCDTDDFVMVPAQFPGDLVA	TP	6HYO	Homo sapiens (Human)	1050

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0074	mutation analysis	in vivo/in vitro	Wirth,2019	support	certain	FeatureDetection
experimental	MI:0114	x-ray crystallography	in vitro	Wirth,2019	support	certain	InteractionDetection FeatureDetection
experimental	MI:0081	peptide array		Wirth,2019	support	certain	InteractionDetection
experimental	MI:0969	biolayer interferometry		Wirth,2019	support	certain	InteractionDetection
experimental	MI:0113	western blot	in vitro	Wirth,2019	support	certain	ParticipantIdentification FeatureDetection

Interactions

Uniprot Id	Domain family	Domain Start	Domain End	Affinity Min/Max (µMol)	Notes
(O95166) GBRAP_HUMAN	PF02991 (Atg8) Autophagy protein Atg8 ubiquitin like	13	116	0.046/0.054	[mitab][xml]
(Q9H0R8) GBRL1_HUMAN	PF02991 (Atg8) Autophagy protein Atg8 ubiquitin like	13	116	0.044/0.052	[mitab][xml]
(P60520) GBRL2_HUMAN	PF02991 (Atg8) Autophagy protein Atg8 ubiquitin like	13	116	0.48/0.58	[mitab][xml]
(Q9H492) MLP3A_HUMAN	PF02991 (Atg8) Autophagy protein Atg8 ubiquitin like	15	120	5.8/6.0	[mitab][xml]
(Q9GZQ8) MLP3B_HUMAN	PF02991 (Atg8) Autophagy protein Atg8 ubiquitin like	15	120	41.8/54.6	[mitab][xml]
(Q9BXW4) MLP3C_HUMAN	PF02991 (Atg8) Autophagy protein Atg8 ubiquitin like	21	126	2.2/2.8	[mitab][xml]

Pathways

KEGG: The sequence O75385 is implicated in the following 10 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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