ELM - instance LIG_KLC1_WD_1 in sequence Q8IWE5 at position 205

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002924	Q8IWE5 PLEKHM2 PKHM2_HUMAN	205	214	VTSTNLEWDDSAIAPSSEDY	TP	3ZFW	Homo sapiens (Human)	1019

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0663	confocal microscopy	in vivo/in vitro	Rosa-Ferreira,2011	support	likely	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Rosa-Ferreira,2011	support	likely	FeatureDetection
experimental	MI:0096	pull down	in vivo/in vitro	Dodding,2011	support	likely	InteractionDetection
experimental	MI:0416	fluorescence microscopy		Dodding,2011	support	likely	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Dodding,2011	support	likely	FeatureDetection
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Dodding,2011	support	likely	InteractionDetection
experimental	MI:0114	x-ray crystallography	in vitro	Pernigo,2013	support	certain	InteractionDetection FeatureDetection
experimental	MI:0053	fluorescence polarization spectroscopy	in vitro	Pernigo,2013	support	certain	InteractionDetection
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Pernigo,2013	support	certain	InteractionDetection

Interactions

Uniprot Id	Domain family	Domain Start	Domain End	Affinity Min/Max (µMol)	Notes
(O88447) KLC1_MOUSE	SM00028 (TPR) Tetratricopeptide repeats.	253	286		[mitab][xml]
(O88448) KLC2_MOUSE	SM00028 (TPR) Tetratricopeptide repeats.	239	272	23.7/23.7	[mitab][xml]

Pathways

KEGG: The sequence Q8IWE5 is implicated in the following 1 Pathway: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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