The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
LIG_Integrin_RGD_TGFB_3

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI004152 P01137 TGFB1
TGFB1_HUMAN 		244 250 GFTTGRRGDLATIHGMNRPF TP 5FFO  
6OM2  
6UJA  
Homo sapiens (Human) 390

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:1088 phenotype-based detection assay Barden,2015 support certain InteractionDetection
experimental MI:1088 phenotype-based detection assay Lu,2002 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Lu,2002 support certain FeatureDetection
experimental MI:0411 elisa in vitro Ozawa,2016 support certain InteractionDetection ParticipantIdentification
experimental MI:0074 mutation analysis in vivo/in vitro Ozawa,2016 support certain FeatureDetection
experimental MI:1088 phenotype-based detection assay Campbell,2020 support certain InteractionDetection
experimental MI:0411 elisa in vitro Campbell,2020 support certain InteractionDetection ParticipantIdentification
experimental MI:0040 electron microscopy in vivo/in vitro Campbell,2020 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Campbell,2020 support certain FeatureDetection
experimental MI:0944 mass spectrometry study of hydrogen/deuterium exchange in vivo/in vitro Wang,2019 support certain InteractionDetection
experimental MI:0053 fluorescence polarization spectroscopy in vitro Wang,2019 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Wang,2019 support certain FeatureDetection
experimental MI:0114 x-ray crystallography in vitro Wang,2019 support certain InteractionDetection FeatureDetection
experimental MI:0053 fluorescence polarization spectroscopy in vitro Dong,2014 support certain InteractionDetection
experimental MI:1088 phenotype-based detection assay Wang,2012 support certain InteractionDetection
experimental MI:0107 surface plasmon resonance in vitro Dong,2017 support certain InteractionDetection FeatureDetection
experimental MI:0114 x-ray crystallography in vitro Dong,2017 support certain InteractionDetection FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P53708) ITA8_HUMAN PF01839 (FG-GAP)
FG-GAP repeat 		321 363 [mitab][xml]
(P06756) ITAV_HUMAN PF01839 (FG-GAP)
FG-GAP repeat 		252 286 0.0072/0.0147 [mitab][xml]
(P05556) ITB1_HUMAN PF00362 (Integrin_beta)
Integrin, beta chain 		138 382 [mitab][xml]
(P05106) ITB3_HUMAN PF00362 (Integrin_beta)
Integrin, beta chain 		133 381 [mitab][xml]
(P18564) ITB6_HUMAN PF00362 (Integrin_beta)
Integrin, beta chain 		128 375 0.0072/0.0147 [mitab][xml]
(P26012) ITB8_HUMAN PF00362 (Integrin_beta)
Integrin, beta chain 		142 388 [mitab][xml]

o  Pathways

KEGG: The sequence P01137 is implicated in the following 34 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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