The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI004678 P43146 DCC
DCC_HUMAN
1425 1443 LSEQMASLEGLMKQLNAITG TP 3AU4  
Homo sapiens (Human) 1447

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0096 pull down in vivo/in vitro Hirano,2011 support likely InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Hirano,2011 support likely FeatureDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Hirano,2011 support likely InteractionDetection
experimental MI:0114 x-ray crystallography in vitro Hirano,2011 support likely InteractionDetection FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(Q9HD67) MYO10_HUMAN IPR041797 (Myosin X, FERM domain C-lobe)
MyoX, a MyTH-FERM myosin, is a molecular motor that has crucial functions in the transport and/or tethering of integrins in the actin-based extensions known as filopodia, microtubule binding, and ...
[mitab][xml]

o  Pathways

KEGG: The sequence P43146 is implicated in the following 3 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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