ELM - instance LIG_FAT_LD_1 in sequence P49023 at position 4

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002433	P49023 PXN PAXI_HUMAN	4	12	MDDLDALLADLESTTSHISK	TP	---	Homo sapiens (Human)	591

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0096	pull down	in vivo/in vitro		support	certain	InteractionDetection
experimental	MI:0521	his tag	in vivo/in vitro/in silico	Li,2010	support	certain
experimental	MI:0096	pull down	in vivo/in vitro		support	certain	InteractionDetection
experimental	MI:0519	glutathione s tranferase tag	in vitro	Nikolopoulos,2001	support	certain
experimental	MI:0096	pull down	in vivo/in vitro		support	certain	InteractionDetection
experimental	MI:0519	glutathione s tranferase tag	in vitro	Turner,1999	support	certain
experimental	MI:0096	pull down	in vivo/in vitro		support	certain	InteractionDetection
experimental	MI:0519	glutathione s tranferase tag	in vitro	Nikolopoulos,2001	support	certain
experimental	MI:0096	pull down	in vivo/in vitro		support	certain	InteractionDetection
experimental	MI:0519	glutathione s tranferase tag	in vitro	Li,2010	support	certain
experimental	MI:0007	anti tag coimmunoprecipitation	in vivo	Li,2010	support	certain	InteractionDetection
experimental	MI:0405	competition binding	in vitro	Li,2010	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Li,2010	support	certain	FeatureDetection
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Nikolopoulos,2001	support	certain	InteractionDetection
experimental	MI:0403	colocalization	in vitro	Nikolopoulos,2001	support	certain
experimental	MI:0074	mutation analysis	in vivo/in vitro	Nikolopoulos,2001	support	certain	FeatureDetection
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Turner,1999	support	certain	InteractionDetection
experimental	MI:0007	anti tag coimmunoprecipitation	in vivo	Nikolopoulos,2001	support	certain	InteractionDetection
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Nikolopoulos,2001	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Nikolopoulos,2001	support	certain	FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000501:

Alternative splicing removes the FAK-binding LD motif of Paxillin (PXN), abrogating binding to Focal adhesion kinase 1 (PTK2).

Pathways

KEGG: The sequence P49023 is implicated in the following 13 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement

feedback@elm.eu.org