| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI002581 | Q702N8 XIRP1 XIRP1_HUMAN |
22 | 26 | RMATAEDLPLPPPPALEDLP | TP | --- | Homo sapiens (Human) | 1843 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0081 | peptide array | van der Ven,2006 | support | certain | InteractionDetection | |
| experimental | MI:0047 | far western blotting | in vitro | van der Ven,2006 | support | certain | InteractionDetection |
| experimental | MI:0018 | two hybrid | in vivo | van der Ven,2006 | support | certain | InteractionDetection |
| experimental | MI:0403 | colocalization | in vitro | van der Ven,2006 | support | certain | |
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | van der Ven,2006 | support | certain | FeatureDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (Q8N8S7) ENAH_HUMAN | PF00568
(WH1)
WH1 domain |
1 | 108 | [mitab][xml] | |
| (Q9UI08) EVL_HUMAN | PF00568
(WH1)
WH1 domain |
1 | 109 | [mitab][xml] | |
| (P50552) VASP_HUMAN | PF00568
(WH1)
WH1 domain |
1 | 110 | [mitab][xml] |
Switches
This ELM instance is part of the following 2 switching mechanisms annotated at the switches.ELM resource:
-
SWTI000584:
Alternative splicing removes the EVH1-binding motif of Xin actin-binding repeat-containing protein 1 (XIRP1), abrogating binding to Protein enabled homolog (ENAH).
-
SWTI000585:
Alternative splicing removes the EVH1-binding motif of Xin actin-binding repeat-containing protein 1 (XIRP1), abrogating binding to Vasodilator-stimulated phosphoprotein (VASP).
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement