ELM - instance LIG_BRCT_MDC1_1 in sequence P16104 at position 139

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI000943	P16104 H2AFX H2AX_HUMAN	139	143	TVGPKAPSGGKKATQASQEY	TP	2AZM	Homo sapiens (Human)	143

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0096	pull down	in vivo/in vitro		support	certain	InteractionDetection
experimental	MI:0519	glutathione s tranferase tag	in vitro	Stucki,2005	support	certain
experimental	MI:0114	x-ray crystallography	in vitro	Stucki,2005	support	certain	InteractionDetection FeatureDetection
experimental	MI:0065	isothermal titration calorimetry	in vitro	Stucki,2005	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Stucki,2005	support	certain	FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000123:

Phosphorylation of S140 in the BRCT-binding motif of Histone H2A.x (H2AFX) induces binding to the Mediator of DNA damage checkpoint protein 1 (MDC1) protein.

Pathways

KEGG: The sequence P16104 is implicated in the following 4 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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