The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI003185 Q14457 BECN1
BECN1_HUMAN
108 124 GTMENLSRRLKVTGDLFDIM TP 2P1L  
Homo sapiens (Human) 450

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0096 pull down in vivo/in vitro support certain InteractionDetection
experimental MI:0519 glutathione s tranferase tag in vitro Oberstein,2007 support certain
experimental MI:0071 molecular sieving in vivo/in vitro Oberstein,2007 support certain InteractionDetection
experimental MI:0114 x-ray crystallography in vitro Oberstein,2007 support certain InteractionDetection FeatureDetection
experimental MI:0065 isothermal titration calorimetry in vitro Oberstein,2007 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Oberstein,2007 support certain FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(Q07817) B2CL1_HUMAN PF00452 (Bcl-2)
Apoptosis regulator proteins, Bcl-2 family
90 188 2.3/2.3 [mitab][xml]

o  Pathways

KEGG: The sequence Q14457 is implicated in the following 12 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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