ELM - instance LIG_AP2alpha_2 in sequence P98082 at position 298

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002610	P98082 DAB2 DAB2_HUMAN	298	300	PNPDPFRDDPFTQPDQSTPS	TP	---	Homo sapiens (Human)	770

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0007	anti tag coimmunoprecipitation	in vivo	Morris,2001	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Morris,2001	support	certain	FeatureDetection
experimental	MI:0096	pull down	in vivo/in vitro	Morris,2001	support	certain	InteractionDetection

Switches

This ELM instance is part of the following 2 switching mechanisms annotated at the switches.ELM resource:

SWTI000573:

Alternative splicing removes the AP2alpha-binding motifs of Disabled homolog 2 (DAB2), abrogating binding to AP-2 complex subunit alpha-2 (AP2A2). The p67 splice variant of Dab1 (also known as Isoform 2) does not localise to vesicles as it fails to bind the AP-2 complex.
SWTI000574:

Alternative splicing removes the AP2alpha-binding motifs of Disabled homolog 2 (DAB2), abrogating binding to AP-2 complex subunit alpha-2 (AP2A2). The p67 splice variant of Dab1 (also known as Isoform 2) does not localise to vesicles as it fails to bind the AP-2 complex.

Pathways

KEGG: The sequence P98082 is implicated in the following 1 Pathway: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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