The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
LIG_ANK_PxLPxL_1

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI002951 P98158 Lrp2
LRP2_RAT 		4460 4468 LLPTLPKLPSLSSLAKPSEN TP 3V2O  
3V2X  
Rattus norvegicus (Norway rat) 4660

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0096 pull down in vivo/in vitro support certain InteractionDetection
experimental MI:0519 glutathione s tranferase tag in vitro Rader,2000 support certain
experimental MI:0416 fluorescence microscopy Rader,2000 support certain InteractionDetection
experimental MI:0113 western blot in vitro Rader,2000 support certain ParticipantIdentification FeatureDetection
experimental MI:0858 immunodepleted coimmunoprecipitation in vitro Rader,2000 support certain InteractionDetection
experimental MI:0007 anti tag coimmunoprecipitation in vivo Rader,2000 support certain InteractionDetection
experimental MI:0018 two hybrid in vivo Rader,2000 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Rader,2000 support certain FeatureDetection
experimental MI:0065 isothermal titration calorimetry in vitro Xu,2012 support certain InteractionDetection
experimental MI:0114 x-ray crystallography in vitro Xu,2012 support certain InteractionDetection FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(Q9H9E1) ANRA2_HUMAN SM00248 (ANK)
ankyrin repeats 		181 210 4.3/5.5 [mitab][xml]
(Q99PE2) ANRA2_MOUSE SM00248 (ANK)
ankyrin repeats 		180 209 [mitab][xml]

o  Pathways

KEGG: The sequence P98158 is implicated in the following 3 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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