ELM - instance LIG_14-3-3_CanoR_1 in sequence Q9GZV5 at position 86

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002991	Q9GZV5 WWTR1 WWTR1_HUMAN	86	91	AGGAQHVRSHSSPASLQLGT	TP	---	Homo sapiens (Human)	400

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0096	pull down	in vivo/in vitro		support	certain	InteractionDetection
experimental	MI:0519	glutathione s tranferase tag	in vitro	Kanai,2001	support	certain
experimental	MI:0096	pull down	in vivo/in vitro		support	likely	InteractionDetection
experimental	MI:0519	glutathione s tranferase tag	in vitro	Kanai,2001	support	likely
experimental	MI:0586	inhibitor		Kanai,2001	support	likely
experimental	MI:0007	anti tag coimmunoprecipitation	in vivo	Kanai,2001	support	likely	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Kanai,2001	support	likely	FeatureDetection
experimental	MI:0586	inhibitor		Kanai,2001	support	certain
experimental	MI:0007	anti tag coimmunoprecipitation	in vivo	Kanai,2001	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Kanai,2001	support	certain	FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000587:

Phosphorylation of S89 in the 14-3-3-binding motif of WW domain-containing transcription regulator protein 1 (WWTR1) induces binding to 14-3-3 protein epsilon (YWHAE), retaining phosphorylated WWTR1 in the cytosol, negatively regulating its function.

Pathways

KEGG: The sequence Q9GZV5 is implicated in the following 2 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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