ELM - instance LIG_14-3-3_CanoR_1 in sequence P46938 at position 109

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002995	P46938 Yap1 YAP1_MOUSE	109	114	ALTPQHVRAHSSPASLQLGA	TP	---	Mus musculus (House mouse)	488

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0363	inferred by author	in silico	Kanai,2001	support	likely	InteractionDetection ParticipantIdentification FeatureDetection
experimental	MI:0064	interologs	in silico	Kanai,2001	support	likely	InteractionDetection
experimental	MI:0363	inferred by author	in silico	Kanai,2001	support	certain	InteractionDetection ParticipantIdentification FeatureDetection
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Kanai,2001	support	certain	InteractionDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000238:

Phosphorylation of S112 in the 14-3-3 binding motif of Yorkie homolog (Yap1) induces binding to the 14-3-3 protein epsilon (Ywhae) protein. 14-3-3 retains phosphorylated YAP in the cytosol, negatively regulating its function.

Pathways

KEGG: The sequence P46938 is implicated in the following 2 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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