Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
---|---|---|---|---|---|---|---|---|
ELMI003028 | P08965 mei2 MEI2_SCHPO |
524 | 529 | TGSLGMRRSLTVGANASCSN | TP | --- | Schizosaccharomyces pombe 972h- | 750 |
Instance evidence
Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
---|---|---|---|---|---|---|---|
experimental | MI:0007 | anti tag coimmunoprecipitation | in vivo | Sato,2002 | support | certain | InteractionDetection |
experimental | MI:0018 | two hybrid | in vivo | Sato,2002 | support | certain | InteractionDetection |
experimental | MI:0405 | competition binding | in vitro | Sato,2002 | support | certain | InteractionDetection |
experimental | MI:0074 | mutation analysis | in vivo/in vitro | Sato,2002 | support | certain | FeatureDetection |
Switches
This ELM instance is part of the following 2 switching mechanisms annotated at the switches.ELM resource:
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SWTI000326:
Binding of meiRNA meiotic non-coding RNA (meiRNA) to the RRM domains of Meiosis protein mei2 (mei2) is essential for promotion of premeiotic DNA synthesis and meiosis I and is blocked by Pat1-mediated phosphorylation-induced binding of the 14-3-3 protein DNA damage checkpoint protein rad24 (rad24) to 2 14-3-3 binding motifs in mei2.
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SWTI000459:
Phosphorylation of two 14-3-3-binding motifs in Meiosis protein mei2 (mei2) by Negative regulator of sexual conjugation and meiosis (ran1) induces high-avidity binding to dimeric DNA damage checkpoint protein rad24 (rad24), with pT527 being the high-affinity interaction site.
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement