| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI002987 | O43524 FOXO3 FOXO3_HUMAN |
29 | 34 | FEPQSRPRSCTWPLQRPELQ | TP | --- | Homo sapiens (Human) | 673 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0005 | alanine scanning | in vivo/in vitro/in silico | Brunet,2002 | support | certain | FeatureDetection |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000355:
Phosphorylation of two 14-3-3-binding motifs in Forkhead box protein O3 (FOXO3) by RAC-alpha serine/threonine-protein kinase (AKT1) induces high-avidity binding to dimeric 14-3-3 protein beta/alpha (YWHAB). This interaction results in cytoplasmic retention and inactivation of Forkhead box protein O3 (FOXO3).
Pathways
- AMPK signaling pathway
- Cellular senescence
- Chemical carcinogenesis reactive oxygen species
- Chemokine signaling pathway
- EGFR tyrosine kinase inhibitor resistance
- Endometrial cancer
- FoxO signaling pathway
- Longevity regulating pathway
- Longevity regulating pathway multiple species
- Mitophagy animal
- Neurotrophin signaling pathway
- Non small cell lung cancer
- PI3K Akt signaling pathway
- Prolactin signaling pathway
- Shigellosis
Please cite:
The Eukaryotic Linear Motif resource: 2022 release.
(PMID:34718738)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement