ELM - instance LIG_14-3-3_CanoR_1 in sequence O15151 at position 364

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002984	O15151 MDM4 MDM4_HUMAN	364	369	NDVPDCRRTISAPVVRPKDA	TP	---	Homo sapiens (Human)	490

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0007	anti tag coimmunoprecipitation	in vivo	Pereg,2006	support	certain	InteractionDetection
experimental	MI:0405	competition binding	in vitro	Pereg,2006	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Pereg,2006	support	certain	FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000682:

Optimal binding of 14-3-3 dimer to Hdmx in response to DNA damage requires phosphorylation of two 14-3-3-binding motifs by Chk2 kinase. Binding of 14-3-3 dimer is involved in inactivation of Hdmx, a negative regulator of p53, in response to DNA damage.

Pathways

KEGG: The sequence O15151 is implicated in the following 2 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement