The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI002984 O15151 MDM4
364 369 NDVPDCRRTISAPVVRPKDA TP --- Homo sapiens (Human) 490

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0007 anti tag coimmunoprecipitation in vivo Pereg,2006 support certain InteractionDetection
experimental MI:0405 competition binding in vitro Pereg,2006 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Pereg,2006 support certain FeatureDetection

o  Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
  • SWTI000682:
    ELM Switch SWTI000682

    Optimal binding of 14-3-3 dimer to Hdmx in response to DNA damage requires phosphorylation of two 14-3-3-binding motifs by Chk2 kinase. Binding of 14-3-3 dimer is involved in inactivation of Hdmx, a negative regulator of p53, in response to DNA damage.

o  Pathways

KEGG: The sequence O15151 is implicated in the following 2 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement