| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI002000 | Q14653 IRF3 IRF3_HUMAN |
336 | 341 | LITFTEGSGRSPRYALWFCV | TP | --- | Homo sapiens (Human) | 427 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0096 | pull down | in vivo/in vitro | support | certain | InteractionDetection | |
| experimental | MI:0519 | glutathione s tranferase tag | in vitro | Saitoh,2006 | support | certain | |
| experimental | MI:0434 | phosphatase assay | in vitro | Saitoh,2006 | support | certain | InteractionDetection |
| experimental | MI:0113 | western blot | in vitro | Saitoh,2006 | support | certain | ParticipantIdentification FeatureDetection |
| experimental | MI:0019 | coimmunoprecipitation | in vivo/in vitro | Saitoh,2006 | support | certain | InteractionDetection |
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | Saitoh,2006 | support | certain | FeatureDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (Q9QUR7) PIN1_MOUSE | PF00397
(WW)
WW domain |
7 | 37 | [mitab][xml] |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000075:
Phosphorylation of S339 in the Pin1-binding motif of Interferon regulatory factor 3 (IRF3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
Pathways
- Coronavirus disease COVID 19
- Cytosolic DNA sensing pathway
- Epstein Barr virus infection
- Hepatitis B
- Hepatitis C
- Herpes simplex virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- Influenza A
- Kaposi sarcoma associated herpesvirus infection
- Lipid and atherosclerosis
- Measles
- NOD like receptor signaling pathway
- Pertussis
- RIG I like receptor signaling pathway
- Shigellosis
- Toll like receptor signaling pathway
- Viral carcinogenesis
- Yersinia infection
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement